Search results
Results from the WOW.Com Content Network
The general structure of a phosphite ester showing the lone pairs on the P. In organic chemistry, a phosphite ester or organophosphite usually refers to an organophosphorous compound with the formula P(OR) 3. They can be considered as esters of an unobserved tautomer phosphorous acid, H 3 PO 3, with the simplest example being trimethylphosphite ...
Phosphite esters with tertiary alkyl halide groups can undergo the reaction, which would be unexpected if only an S N 2 mechanism was operating. Further support for this S N 1 type mechanism comes from the use of the Arbuzov reaction in the synthesis of neopentyl halides, a class of compounds that are notoriously unreactive towards S N 2 reactions.
Since orthophosphoric acid has three −OH groups, it can esterify with one, two, or three alcohol molecules to form a mono-, di-, or triester. See the general structure image of an ortho- (or mono-) phosphate ester below on the left, where any of the R groups can be a hydrogen or an organic radical. Di- and tripoly- (or tri-) phosphate esters ...
Various specialised methods have been developed on the laboratory-scale for scientific investigations. These are rarely employed in bulk manufacturing. Examples include the Atherton-Todd reaction, which converts a dialkyl phosphite to a phosphoryl chloride. This can then react with an alcohol to give an organophosphate and HCl.
Structural formula of Na 2 HPO 3.The anion has C 3v symmetry.. From the commercial perspective, the most important phosphite salt is basic lead phosphite.Many salts containing the phosphite ion have been investigated structurally, these include sodium phosphite pentahydrate (Na 2 HPO 3 ·5H 2 O).
The mechanism starts with an allylic sulfoxide 1 which undergoes a thermal 2,3-sigmatropic rearrangement to give a sulfenate ester 2. This can be cleaved using a thiophile, such as phosphite ester , which leaves the allylic alcohol 3 as the product.
With the formula (HO) 2 P(O)CH 2 NHCH 2 CO 2 H, this derivative of glycine is one of the most widely used herbicides. Bisphosphonates are a class of drugs to treat osteoporosis. The nerve gas agent sarin, containing both C–P and F–P bonds, is a phosphonate. [citation needed] Phosphinates feature two P–C bonds, with the general formula R 2 ...
It reacts with phenol to give triphenyl phosphite: 3 PhOH + PCl 3 → P(OPh) 3 + 3 HCl (Ph = C 6 H 5) Alcohols such as ethanol react similarly in the presence of a base such as a tertiary amine: [9] PCl 3 + 3 EtOH + 3 R 3 N → P(OEt) 3 + 3 R 3 NH + Cl −. With one equivalent of alcohol and in the absence of base, the first product is ...