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Vaccine contamination with Simian vacuolating virus 40, known as SV40 occurred in the United States and other countries between 1955 and 1961.. SV40 is a monkey virus that has the potential to cause cancer in animals and humans, although this is considered very unlikely and there have been no known human cases. [1]
The hypothesis that SV40 might cause cancer in humans was a particularly controversial area of research, fuelled by the historical contamination of some batches of polio vaccine with SV40 in the 1950s and 1960s. [4] "Persuasive evidence now indicates that SV40 is causing infections in humans today and represents an emerging pathogen."
The polio vaccine has all but obliterated the illness that once killed thousands and paralyzed 15,000 people nationwide every year. ... is a distinctly contagious illness caused by a virus called ...
Poliomyelitis (/ ˌ p oʊ l i oʊ ˌ m aɪ ə ˈ l aɪ t ɪ s / POH-lee-oh-MY-ə-LY-tiss), commonly shortened to polio, is an infectious disease caused by the poliovirus. [1] Approximately 75% of cases are asymptomatic; [5] mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia.
By 1961, only 161 cases of polio were documented. Before the vaccine, the disease had been a major cause of disability in children, according to theMayo Clinic. Several polio epidemics occurred ...
The polio vaccine available in the United States is recommended for children and three doses offer at least 99% protection against severe disease, including paralysis, according to the CDC.
However, a 1999 study is among those that find that "increased incidence of certain cancers among the 98 million persons exposed to contaminated polio vaccine in the U.S." [22] The question of whether SV40 causes cancer in humans remains controversial, however, and the development of improved assays for detection of SV40 in human tissues will ...
Two vaccines are used throughout the world to combat poliomyelitis.The first, a polio vaccine developed by Jonas Salk, is an inactivated poliovirus vaccine (IPV), consisting of a mixture of three wild, virulent strains of poliovirus, grown in a type of monkey kidney tissue culture (Vero cell line), and made noninfectious by formaldehyde treatment.