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An analogy for the Hox genes can be made to the role of a play director who calls which scene the actors should carry out next. If the play director calls the scenes in the wrong order, the overall play will be presented in the wrong order. Similarly, mutations in the Hox genes can result in body parts and limbs in the wrong place along the body.
Hox genes are found in bilateral animals, including Drosophila (in which they were first discovered) and humans. Hox genes are a subset of the homeobox genes. The Hox genes are often conserved across species, so some of the Hox genes of Drosophila are homologous to those in humans. In general, Hox genes play a role of regulating expression of ...
Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene. [ 5 ] [ 6 ] [ 7 ] This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.
Hox genes are typically found in an organized cluster. The linear order of Hox genes within a cluster is directly correlated to the order in which they are expressed in both time and space during development. This phenomenon is called colinearity. Mutations in these homeotic genes cause
The mutation Antennapedia The two Hox gene complexes in fruit flies. Antennapedia (abbreviated Antp) is a Hox gene first discovered in Drosophila which controls the formation of legs during development. Loss-of-function mutations in the regulatory region of this gene result in the development of the second leg pair into ectopic antennae.
Homeosis may be caused by mutations in Hox genes, found in animals, or others such as the MADS-box family in plants. Homeosis is a characteristic that has helped insects become as successful and diverse as they are. [3] Homeotic mutations work by changing segment identity during development.
10481 15408 Ensembl ENSG00000159184 ENSMUSG00000049604 UniProt Q92826 P70321 RefSeq (mRNA) NM_006361 NM_008267 RefSeq (protein) NP_006352 NP_032293 Location (UCSC) Chr 17: 48.72 – 48.73 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13 gene. Function This gene encodes a transcription factor that belongs ...
3209 15398 Ensembl ENSG00000106031 ENSMUSG00000038203 UniProt P31271 Q62424 RefSeq (mRNA) NM_000522 NM_008264 RefSeq (protein) NP_000513 NP_032290 Location (UCSC) Chr 7: 27.19 – 27.2 Mb Chr 6: 52.23 – 52.24 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-A13 is a protein that in humans is encoded by the HOXA13 gene. Function In vertebrates, the genes encoding ...