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The Hantzsch pyridine synthesis typically uses a 2:1:1 mixture of a β-keto acid (often acetoacetate), an aldehyde (often formaldehyde), and ammonia or its salt as the nitrogen donor. First, a double hydrogenated pyridine is obtained, which is then oxidized to the corresponding pyridine derivative.
3-Hydroxyisonicotinaldehyde (HINA), also known as 3-hydroxypyridine-4-carboxaldehyde, is a derivative of pyridine, with hydroxyl and aldehyde substituents. It has been studied as a simple analogue of vitamin B 6. In 2020, it was reported as having the lowest molecular weight of all dyes which exhibit green fluorescence. [2] [3]
The amide group can be involved in hydrogen bonding to other nitrogen- and oxygen-containing species.. The predominant solid state form is 2-pyridone. This has been confirmed by X-ray crystallography which shows that the hydrogen in solid state is closer to the nitrogen than to the oxygen (because of the low electron density at the hydrogen the exact positioning is difficult), and IR ...
N-Methyl-3-piperidyl benzilate (JB-336, BZ) Piperidine is also commonly used in chemical degradation reactions, such as the sequencing of DNA in the cleavage of particular modified nucleotides . Piperidine is also commonly used as a base for the deprotection of Fmoc - amino acids used in solid-phase peptide synthesis .
It is an electrophilic source of oxygen that reacts with enolates and related structures, and thus can be used for alpha-hydroxylation of carbonyl-containing compounds. [3] Other reagents used for alpha-hydroxylation via enol or enolate structures include Davis oxaziridine , oxygen , and various peroxyacids (see Rubottom oxidation ).
Isonicotinic acid or pyridine-4-carboxylic acid is an organic compound with the formula C 5 H 4 N(CO 2 H). It is a derivative of pyridine with a carboxylic acid substituent at the 4-position. It is an isomer of picolinic acid and nicotinic acid , which have the carboxyl group at the 2- and 3-position respectively compared to the 4-position for ...
Pyridine-N-oxide is the heterocyclic compound with the formula C 5 H 5 NO. This colourless, hygroscopic solid is the product of the oxidation of pyridine. It was originally prepared using peroxyacids as the oxidising agent. The compound is used infrequently as an oxidizing reagent in organic synthesis. [1]
N-Hydroxypiperidine (also known as 1-piperidinol and 1-hydroxypiperidine) is the chemical compound with formula C 5 H 11 NO. It is a hydroxylated derivative of the heterocyclic compound piperidine . Preparation