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6-MeO-DMT, or 6-methoxy-N,N-dimethyltryptamine, also known as 6-OMe-DMT, is a serotonergic drug of the tryptamine family. [ 1 ] [ 2 ] It is the 6- methoxy derivative of the serotonergic psychedelic N , N -dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT .
[164] [166] [167] Similarly to DMT, 5-MeO-DMT is a biased agonist of the serotonin 5-HT 2A receptor, with minimal β-arrestin2 recruitment, and likewise has been associated with little tolerance to its hallucinogenic effects. [168] [142] As DMT has been shown to have slightly better efficacy (EC 50) at human serotonin 2C receptor than at the 2A ...
Later analysis tentatively found 5-MeO-DMT in stems, leaves and roots; DMT, NMT and 5-MeO-DMT were tentatively observed in seeds, but follow-up tests were negative. [ 9 ] [ 53 ] Bark contains unidentified alkaloids [ 54 ] Bark in one sample subsequently found to contain an alkaloid which has an Rf value suggesting DMT.
This combination's goal is to prolong the empathogenic effects of MDMA and the psychedelic effects of LSD. The idea is to have be able to experience an enhanced "Candyflipping" with a smoother comedown. The whole experience is long-lasting and can be too intense as all of these molecules synergize and potentiate each other. 2C-B: MDMA: Nexus ...
2,N,N-trimethyltryptamine, 2,N,N-TMT, or 2-Me-DMT is a tryptamine derivative that is a psychedelic drug. It was invented by Alexander Shulgin and reported in his book TiHKAL (#34). [ 1 ]
Psilacetin, also known as O-acetylpsilocin or as 4-acetoxy-N,N-dimethyltryptamine (4-acetoxy-DMT or 4-AcO-DMT), is a semi-synthetic serotonergic psychedelic drug that has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin.
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[1] α,N-DMT is known to be a potent monoamine oxidase inhibitor and tryptamine or serotonin receptor antagonist. [2] [1] Close analogues of α,N-DMT, such as α-methyltryptamine (αMT), are known to act as monoamine releasing agents and serotonin receptor agonists. [3] α,N-DMT is the N-methylated analogue of αMT. [1]