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The term variant of concern (VOC) for SARS-CoV-2, which causes COVID-19, is a category used for variants of the virus where mutations in their spike protein receptor binding domain (RBD) substantially increase binding affinity (e.g., N501Y) in RBD-hACE2 complex (genetic data), while also being linked to rapid spread in human populations ...
“Variants that can infect people better or evade immunity to the last variant are more likely to cause a new COVID wave,” Peter Kasson, M.D., Ph.D., B.S., of the University of Virginia’s ...
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Distinct from the PANGOLIN tool, Pango lineages are regularly, manually curated based on the current globally circulating diversity. A large phylogenetic tree is constructed from an alignment containing publicly available SARS-CoV-2 genomes, and sub-clusters of sequences in this tree are manually examined and cross-referenced against epidemiological information to designate new lineages; these ...
FLiRT variants are subvariants of omicron and were responsible for most COVID-19 cases in the U.S. by the beginning of July 2024. The KP.1 and KP.2 strains of FLiRT are the dominant strains of the ...
Theta variant, also known as lineage P.3, [a] is one of the variants of SARS-CoV-2, the virus that causes COVID-19. The variant was first identified in the Philippines on February 18, 2021, when two mutations of concern were detected in Central Visayas . [ 1 ]
The continued spread of the SARS-CoV-2 virus has spawned a Greek alphabet of variants - a naming system used by the World Health Organization to track concerning new mutations of the virus that ...
Iota variant, [1] also known as lineage B.1.526, is one of the variants of SARS-CoV-2, the virus that causes COVID-19. It was first detected in New York City in November 2020. The variant has appeared with two notable mutations: the E484K spike mutation, which may help the virus evade antibodies, and the S477N mutation, which helps the virus ...