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Type 1 von Willebrand Disease in dogs. Type 1 von Willebrand Disease is the most common type, and also the mildest. It occurs when dogs have a mild deficiency in all the proteins making up their ...
Von Willebrand disease (VWD) is the most common hereditary blood-clotting disorder in humans. An acquired form can sometimes result from other medical conditions. [ 1 ] It arises from a deficiency in the quality or quantity of von Willebrand factor (VWF), a multimeric protein that is required for platelet adhesion .
PCR serology tests may be performed to screen for diseases. [13] Serum chemistry, coagulation panels, and Coombs tests can be performed to rule out or diagnose comorbidities including: von Willebrand's disease, haemophilia A, disseminated intravascular coagulation, immune-mediated haemolytic anaemia, or renal failure. [3] [14]
von Willebrand disease* is a common inherited disease in dogs caused by a deficiency of a protein called von Willebrand factor, which is involved in blood clotting. The disease varies from mild to severe, depending on the amount of von Willebrand factor present in the dog.
Some of the most common conditions include hip dysplasia seen in large breed dogs; von Willebrand disease a disease that affects platelets that is inherited in Doberman Pinschers; entropion a curling in of the eyelid seen in Shar Peis and many other breeds; progressive retinal atrophy inherited in many breeds; deafness and epilepsy known to be ...
Von Willebrand disease [8] Joint damage, potentially with severe pain and even destruction of the joint and development of arthritis: Hemophilia [7] Von Willebrand disease [8] Retinal bleeding: Acute leukemia [5] Transfusion transmitted infection, from blood transfusions that are given as treatment. Hemophilia [7] Adverse reactions to clotting ...
The differential diagnosis for Bernard–Soulier syndrome includes both Glanzmann thrombasthenia and pediatric Von Willebrand disease. [5] BSS platelets do not aggregate to ristocetin, and this defect is not corrected by the addition of normal plasma, distinguishing it from von Willebrand disease. [4]
In addition, desmopressin (DDAVP) is known to be effective in people with von Willebrand's disease, [17] [18] including people with valvular heart disease. [19] [20] Desmopressin stimulates release of von Willebrand factor from blood vessel endothelial cells by acting on the V2 receptor, which leads to decreased breakdown of Factor VIII.