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3,5-T 2 is an active thyroid hormone. It stimulates the TR-beta receptor for thyroid hormones and thus increases energy expenditure. [1] [2] It has agonistic (thyromimetic) effects at myocardial tissue and pituitary, which results in 3,5-T 2 suppressing TSH release.
The thyroid system of the thyroid hormones T 3 and T 4 [1] Thyroid hormones are two hormones produced and released by the thyroid gland, triiodothyronine (T 3) and thyroxine (T 4). They are tyrosine-based hormones that are primarily responsible for regulation of metabolism. T 3 and T 4 are partially composed of iodine, derived from food. [2]
Like during fetal development, thyroid hormone levels are low in the overloaded heart tissue in a local hypothyroid state, with low levels of deiodinase 1 and deiodinase 2. Although deiodinase 3 levels in a normal heart are generally low, in cardiomyopathy deiodinase 3 activity is increased to decrease energy turnover and oxygen consumption. [7]
Thyroid function tests (TFTs) is a collective term for blood tests used to check the function of the thyroid. [1] TFTs may be requested if a patient is thought to suffer from hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid), or to monitor the effectiveness of either thyroid-suppression or hormone replacement therapy.
Liothyronine is a manufactured form of the thyroid hormone triiodothyronine (T 3). [2] It is most commonly used to treat hypothyroidism and myxedema coma. [2] It can be taken by mouth or by injection into a vein.
At the cellular level, T 3 is the body's more active and potent thyroid hormone. [2] T 3 helps deliver oxygen and energy to all of the body's cells, its effects on target tissues being roughly four times more potent than those of T 4. [2] Of the thyroid hormone that is produced, just about 20% is T 3, whereas 80% is produced as T 4.
thyroid stimulating hormone: TSH: Thoughts of self-harm: TSHR-Ab: thyrotropin-receptor antibody TSI: Thyroid Stimulating Immunoglobulin: T.S.T.H. too sick to send home TT: Thrombin Time. Tubes Tied. TTE: transthoracic echocardiogram: TTG: tissue transglutaminase: TTN: transient tachypnea of the newborn TTO
Iodotyrosine deiodinase contributes to breakdown of thyroid hormones. It releases iodine , for renewed use, from iodinated tyrosines resulting from catabolism of iodothyronines. Iodotyrosine deiodinase employs a flavin mononucleotide cofactor and belongs to the NADH oxidase/flavin reductase superfamily.