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Orthomolecular psychiatry began with Abram Hoffer and Humphry Osmond in the 1950s and was continued by Carl Pfeiffer, [1] although proponents of orthomolecular psychiatry say that the ideas behind their approach can be traced back to the 1920s and '30s.
Pyrrole is a heterocyclic, aromatic, organic compound, a five-membered ring with the formula C 4 H 4 NH. [3] It is a colorless volatile liquid that darkens readily upon exposure to air.
Cyclic tetrapyrroles having four one-carbon bridges include: [1] Porphin, the simplest tetrapyrrole; Porphyrins, including heme, the core of hemoglobin; Chlorins, including those at the core of chlorophyll.
This articles does not state clearly enough that Hoffer is a proto-orthomolecular, that mainstream medicine does not recognise this condition (see Pubmed:Pyroluria) and that it therefore not seen as an explanation for the symptoms/conditions listed.
The mechanism requires zinc and acetic acid as catalysts. It will proceed at room temperature. Because α-aminoketones self-condense very easily, they must be prepared in situ.
Porphyria / p ɔːr ˈ f ɪr i ə / is a group of disorders in which substances called porphyrins build up in the body, adversely affecting the skin or nervous system. [1] The types that affect the nervous system are also known as acute porphyria, as symptoms are rapid in onset and short in duration. [1]
In organic chemistry, an oxime is an organic compound belonging to the imines, with the general formula RR’C=N−OH, where R is an organic side-chain and R' may be hydrogen, forming an aldoxime, or another organic group, forming a ketoxime.
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