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Drug reaction (vomiting may occur as an acute somatic response to): [citation needed] Alcohol, which can be partially oxidized into acetaldehyde that causes the symptoms of hangover, including nausea, vomiting, shortness of breath, and fast heart rate. [22] Opioids; Selective serotonin reuptake inhibitors; Many chemotherapy drugs
The 5-HT 3 receptor antagonists suppress vomiting and nausea by inhibiting serotonin binding to the 5-HT 3 receptors. The highest concentration of 5-HT 3 receptors in the central nervous system are found in the STN and chemoreceptor trigger zone (CTZ), and 5-HT 3 antagonists may also suppress vomiting and nausea by acting at these sites. [29]
Nausea and vomiting associated with migraine headaches respond best to dopamine antagonists such as metoclopramide, prochlorperazine, and chlorpromazine. [22] In cases of gastroenteritis, serotonin antagonists such as ondansetron were found to suppress nausea and vomiting, as well as reduce the need for IV fluid resuscitation. [ 22 ]
Dopamine receptor flow chart. Dopamine receptors are all G protein–coupled receptors, and are divided into two classes based on which G-protein they are coupled to. [1] The D 1-like class of dopamine receptors is coupled to Gα s/olf and stimulates adenylate cyclase production, whereas the D 2-like class is coupled to Gα i/o and thus inhibits adenylate cyclase production.
The ILR monitors the electrical activity of the heart, continuously storing information in its circular memory (hence the name "loop" recorder) as electrocardiograms (ECGs). Abnormal electrical activity - arrhythmia is recorded by "freezing" a segment of the memory for later review.
The neurotransmitters implicated in the control of nausea and vomiting include acetylcholine, dopamine, histamine (H1 receptor), substance P (NK-1 receptor), and serotonin (5-HT3 receptor). There are also opioid receptors present, which may be involved in the mechanism by which opiates cause nausea and vomiting.
The monitor showed his heart rate was at 164 beats per minute (bpm) at the start of his daughter’s routine. But his heart rate jumped up to 181 bpm as he continued to watch.
An antiemetic is a drug that is effective against vomiting and nausea.Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer.
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