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Most of the first generation microbicides were formulated as semi-solid systems, such as gels, tablets, films, or creams, and were designed to be applied to the vagina before every act of intercourse. However, vaginal rings have the potential to provide long-term controlled release of microbicide drugs.
Promestriene (INN Tooltip International Nonproprietary Name) (brand names Colpotrofin, Colpotrophine, Delipoderm), also known as estradiol 3-propyl 17β-methyl diether, is a synthetic estrogen which is used topically in a 1% cream formulation for the treatment of vaginal atrophy in women.
Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix) with limited systemic adverse effects compared to other routes of administration ...
Vaginal insertion: Every act of intercourse: Spermicidal gel, suppository, or film [38] 21 (1 in 5) 16 (1 in 6.25) Spermicide: Vaginal insertion: Every act of intercourse: 1988 cervical cap and spermicide used by parous (discontinued in 2005) [note 5] Prentif: 32 (1 in 3) 26 (1 in 4) Barrier & spermicide: Vaginal insertion: Every act of intercourse
This study focused on the drug as an 80 mg vaginal suppository, taken three times overnight by 10 women. [4] In another placebo-controlled, double blind study by Schmidt et al., the efficacy of different concentrations of terconazole creams were tested. Cream was applied for three days to 24 women between the ages of 18 and 60.
A 2021 study examined the effectiveness of aloe vera vaginal cream for the treatment of atrophic vaginitis. This randomized, double-blind, controlled trial compared the effectiveness of Aloe Vera vaginal cream to estrogen vaginal cream in treating vaginal atrophy in 60 postmenopausal women. [39]
Vaginal infections Nystatin is also used to treat fungal infections in the vaginal area. It is commonly formulated into pessaries or vaginal cream for application. Ointments, gels, creams or dusting powder may be used when patients develop cutaneous lesions. Skin irritations may occur in some patients after applying the medication vaginally.
Vagisil is an American brand of over-the-counter cream used to treat external vaginal itching and irritation. It is produced by Combe Incorporated, a company based in White Plains, New York and was introduced in 1974.
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