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Gamma-glutamyltransferase (also γ-glutamyltransferase, GGT, gamma-GT, gamma-glutamyl transpeptidase; [1] EC 2.3.2.2) is a transferase (a type of enzyme) that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate).
In enzymology, an agaritine gamma-glutamyltransferase (EC 2.3.2.9) is an enzyme that catalyzes the chemical reaction agaritine + acceptor ⇌ {\displaystyle \rightleftharpoons } 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor
TG2 is a multifunctional enzyme that belongs to transglutaminases which catalyze the crosslinking of proteins by epsilon-(gamma-glutamyl)lysine isopeptide bonds. [15] Similarly to other transglutaminases, tTG consists of a GTP/ GDP binding site, a catalytic domain , two beta barrel and a beta-sandwich . [ 16 ]
Human gamma-glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion.
GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors.
Protein-glutamine gamma-glutamyltransferase E is an enzyme that in humans is encoded by the TGM3 gene. [ 5 ] [ 6 ] [ 7 ] Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds.
Gamma-glutamyltransferase is a membrane-associated protein involved in both glutathione metabolism and the transpeptidation of amino acids. Changes in gamma-glutamyltransferase activity may signal preneoplastic or toxic conditions in the liver or kidney.
Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene. [5] [6] [7] [8]Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4).