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A leprostatic agent is a drug that interferes with proliferation of the bacterium that causes leprosy. [1] [2] The following agents are leprostatic agents: [3] acedapsone; clofazimine; dapsone; desoxyfructo-serotonin; diucifon; ethionamide; rifampicin; rifapentine; sulfameter; thalidomide; Leprosy is a chronic infectious disease caused by ...
Treatment of paucibacillary leprosy is with the medications dapsone, rifampicin, and clofazimine for six months. [9] Treatment for multibacillary leprosy uses the same medications for 12 months. [9] A number of other antibiotics may also be used. [3] These treatments are provided free of charge by the World Health Organization. [4]
The primary use of clofazimine is for the treatment of leprosy. [1] Other uses have not been proven to be safe or effective. [1]It has been studied in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in people with HIV/AIDS and Mycobacterium avium paratuberculosis.
Dapsone by mouth was one of the first medications used to treat moderate to severe acne vulgaris, and is still occasionally prescribed for the treatment of severe cases. [10] [11] A topical form of dapsone is also effective with potentially less side effects. [12] It is unclear if the combination with pyrimethamine is useful in the prevention ...
MDT is used to treat leprosy because treatment of leprosy with one drug (monotherapy) can result in drug resistance. The drug combination used in MDT will depend on the classification of the disease. WHO recommends patients with multibacillary leprosy use a combination of Rifampicin, Clofazimine, and Dapsone for 12 months.
Thalidomide, sold under the brand names Contergan and Thalomid among others, is an oral medication used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications of leprosy such as skin lesions).
Promin, or sodium glucosulfone is a sulfone drug that was investigated for the treatment of malaria, [1] tuberculosis [2] and leprosy. [3] [4] It is broken down in the body to dapsone, which is the therapeutic form. [5]
The 1941 development of sulfone therapy, a type of chemotherapy, made leprosy non-contagious. [13] Dapsone pills became widely used for treating leprosy in the 1950s. In 1981, The World Health Organization recommended using a multi-drug treatment regimen to treat leprosy.