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  2. Metaphase - Wikipedia

    en.wikipedia.org/wiki/Metaphase

    These chromosomes, carrying genetic information, align in the equator of the cell between the spindle poles at the metaphase plate, before being separated into each of the two daughter nuclei. This alignment marks the beginning of metaphase. [2] Metaphase accounts for approximately 4% of the cell cycle's duration. [citation needed]

  3. Spindle checkpoint - Wikipedia

    en.wikipedia.org/wiki/Spindle_checkpoint

    The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during metaphase of mitosis or meiosis that prevents the separation of the duplicated chromosomes until each chromosome is properly attached to the ...

  4. Spindle apparatus - Wikipedia

    en.wikipedia.org/wiki/Spindle_apparatus

    The cellular spindle apparatus includes the spindle microtubules, associated proteins, which include kinesin and dynein molecular motors, condensed chromosomes, and any centrosomes or asters that may be present at the spindle poles depending on the cell type. [4] The spindle apparatus is vaguely ellipsoid in cross

  5. Meiotic recombination checkpoint - Wikipedia

    en.wikipedia.org/wiki/Meiotic_recombination...

    Meiotic recombination may begin with a double-strand break, either induced by Spo11 [2] or by other endogenous or exogenous causes of DNA damage. These DNA breaks must be repaired before metaphase I. and these DSBs must be repaired before metaphase I. The cell monitor these DSBs via ATM pathway, in which Cdc25 is suppressed when DSB lesion is ...

  6. Kinetochore - Wikipedia

    en.wikipedia.org/wiki/Kinetochore

    The spindle checkpoint, or SAC (for spindle assembly checkpoint), also known as the mitotic checkpoint, is a cellular mechanism responsible for detection of: correct assembly of the mitotic spindle; attachment of all chromosomes to the mitotic spindle in a bipolar manner; congression of all chromosomes at the metaphase plate.

  7. Mad2 - Wikipedia

    en.wikipedia.org/wiki/MAD2

    The spindle checkpoint system is a regulatory system that restrains progression through the metaphase-to-anaphase transition. The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons. [ 1 ]

  8. JoJo Siwa 'Pledged' Not to Share Dating Life Publicly After ...

    www.aol.com/jojo-siwa-pledged-not-share...

    She had joined in 2015 for season 5. Following her time on the reality show, Siwa found success upon signing on with Nickelodeon. She acted in many of the network's shows and television films, ...

  9. Cell cycle checkpoint - Wikipedia

    en.wikipedia.org/wiki/Cell_cycle_checkpoint

    However, Cyclin D:Cdk 4/6 also phosphorylates p107 and p130, a process which releases their bind from E2F 4 and 5 (which then escape to the cytoplasm), and allowing for E2F 1–3 to bind to the DNA and initiate transcription of Cyclin E. [10] Rb proteins maintain their mono-phosphorylated state during early G1 phase, while Cyclin E is ...

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