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Doxylamine succinate is the active ingredient in many over-the-counter sleep aids branded under various names. Doxylamine succinate and pyridoxine (Vitamin B6) are the ingredients of Diclegis, approved by the FDA in April 2013 becoming the only drug approved for morning sickness [46] with a class A safety rating for pregnancy (no evidence of risk).
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
The recommended adult dose contains: Acetaminophen (650 mg/30 mL) (pain reliever/fever reducer) Dextromethorphan (30 mg/30 mL) (cough suppressant) Doxylamine succinate (12.5 mg/30 mL) (antihistamine/hypnotic) Alcohol (10% by volume) The LiquiCap capsule version has the following active ingredients per pill, half the recommended adult dose:
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Signs and symptoms of pregnancy are common, benign conditions that result from the changes to the body that occur during pregnancy. Signs and symptoms of pregnancy typically change as pregnancy progresses, although several symptoms may be present throughout. Depending on severity, common symptoms in pregnancy can develop into complications. [1]
[12] [61] Aside from diphenhydramine and doxylamine, which have historical approval as hypnotics, doxepin is the only H 1 receptor antagonist that is specifically approved for the treatment of insomnia in the United States. [61] [62] The effect sizes of very low-dose doxepin in the treatment of insomnia range from small to medium. [12]
The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, ...
The safety profile of fexofenadine is quite favorable, as no cardiovascular or sedative effects have been shown to occur even when taking 10 times the recommended dose. [25] Research on humans ranges from a single 800-mg dose, to a twice-daily, 690-mg dose for a month, with no clinically significant adverse effects, when compared to a placebo .
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