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Bacterial initiation factor-2 is a bacterial initiation factor. [1] IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNA f binds to the IF2 then IF2 transfers the tRNA into the partial P site.
Eukaryotic Initiation Factor 2 (eIF2) is an eukaryotic initiation factor.It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNA i Met to the ribosome in a GTP-dependent manner. eIF2 is a heterotrimer consisting of an alpha (also called subunit 1, EIF2S1), a beta (subunit 2, EIF2S2), and a gamma (subunit 3, EIF2S3) subunit.
The initiation factor interacts with the eIF1 and eIF5 factors used for scanning and selection of the start codons. This can create changes in the selection of the factors, binding to different codons. [8] Another important eukaryotic initiation factor, eIF2, binds the tRNA containing methionine to the P site of the small ribosome. The P site ...
The IF2 initiation factor is a crucial component in the process of protein synthesis. The largest among the three indispensable translation initiation factors is IF-2, which possesses a molecular mass of 97 kDa. [17] [18] The protein has many domains, including an N-terminal domain, a GTPase domain, a linker region, C1, C2, and C-terminal domains.
Eukaryotic initiation factors (eIFs) are proteins or protein complexes involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of ribosomal preinitiation complexes around the start codon and are an important input for post-transcription gene regulation .
1965 13665 Ensembl ENSG00000134001 ENSMUSG00000021116 UniProt P05198 Q6ZWX6 RefSeq (mRNA) NM_004094 NM_026114 RefSeq (protein) NP_004085 NP_080390 Location (UCSC) Chr 14: 67.36 – 67.39 Mb Chr 12: 78.91 – 78.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene ...
Initiation of translation in bacteria involves the assembly of the components of the translation system, which are: the two ribosomal subunits (50S and 30S subunits); the mature mRNA to be translated; the tRNA charged with N-formylmethionine (the first amino acid in the nascent peptide); guanosine triphosphate (GTP) as a source of energy, and the three prokaryotic initiation factors IF1, IF2 ...
Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene. [5] [6] [7]During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner.