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Slot-die coating is a non-contact coating method, in which the slot-die is typically held over the substrate at a height several times higher than the target wet film thickness. [23] The coating fluid transfers from the slot-die to the substrate via a fluid bridge that spans the air gap between the slot-die lips and substrate surface.
A film coating is a thin polymer-based coat that is typically sprayed onto solid pharmaceutical dosage forms, such as tablets, capsules, pellets or granules. Film coating can impact both its appearance and its pharmacokinetics making it an essential process in making the final drug product.
There are two types of coating machines used in the pharmaceutical industry: coating pans and automatic coaters. [14] Coating pans are used mostly to sugar coat pellets. Automatic coaters are used for all kinds of coatings; they can be equipped with a remote control panel, a dehumidifier, and dust collectors.
ACG Engineering provides Machines for the oral Solid dosage part of the pharma industry, right from granulation equipment, capsule filling machines, tablet press, tablet coaters, tablet tooling, and packaging machines like blister packing and Cartoning machines. [10] ACG has completed more than 20,000 machine installations. [11]
In 1959, Werner Glatt and a dozen employees designed and installed the very first fluid bed dryer used in the pharmaceutical industry worldwide. Further developments evolved; after drying technology came granulation technology, then coating and finally pelletizing technology.
The BFS process functions similarly to conventional extrusion blow molding, and takes place within a BFS machine. [6] First, a plastic polymer resin is heated to >160 °C and compressed to 35 MPa, [11] [15] allowing it to be extruded in tubular form, [1] and be taken over by an open two-part [16] mold to form the container.
Pharmaceutical manufacturing is the process of industrial-scale synthesis of pharmaceutical drugs as part of the pharmaceutical industry. The process of drug manufacturing can be broken down into a series of unit operations , such as milling , granulation , coating , tablet pressing , and others.
Microencapsulation is a process in which tiny particles or droplets are surrounded by a coating to give small capsules, with useful properties. [1] [2] In general, it is used to incorporate food ingredients, [3] enzymes, cells or other materials on a micro metric scale.
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