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Some interactions may be due to the pH increase observed in the stomach following antacid ingestion, leading to increased absorption of weak acids, and decreased absorption of weak bases. [citation needed] Antacids also cause an increase in pH of the urine (alkalization), which may cause increased blood concentrations of weak bases, and ...
A weak acid cannot always be neutralized by a weak base, and vice versa. However, for the neutralization of benzoic acid (K a,A = 6.5 × 10 −5) with ammonia (K a,B = 5.6 × 10 −10 for ammonium), K = 1.2 × 10 5 >> 1, and more than 99% of the benzoic acid is converted to benzoate.
Bases of carbon, nitrogen and oxygen without resonance stabilization are usually very strong, or superbases, which cannot exist in a water solution due to the acidity of water. Resonance stabilization, however, enables weaker bases such as carboxylates; for example, sodium acetate is a weak base.
As an antacid, magnesium hydroxide is dosed at approximately 0.5–1.5 g in adults and works by simple neutralization, in which the hydroxide ions from the Mg(OH) 2 combine with acidic H + ions (or hydronium ions) produced in the form of hydrochloric acid by parietal cells in the stomach, to produce water.
Under the generic name "algeldrate", aluminium hydroxide is used as an antacid in humans and animals (mainly cats and dogs). It is preferred over other alternatives such as sodium bicarbonate because Al(OH) 3 , being insoluble, does not increase the pH of stomach above 7, and hence does not trigger secretion of excess acid by the stomach.
Acid-neutralizing capacity or ANC in short is a measure for the overall buffering capacity against acidification of a solution, e.g. surface water or soil water.. ANC is defined as the difference between cations of strong bases and anions of strong acids (see below), or dynamically as the amount of acid needed to change the pH value from the sample's value to a chosen different value. [1]
The charge of a molecule depends upon the pH of its solution. In an acidic medium, basic drugs are more charged and acidic drugs are less charged. The converse is true in a basic medium. For example, Naproxen is a non-steroidal anti-inflammatory drug that is a weak acid (its pKa value is 5.0). The gastric juice has a pH of 2.0. It is a three ...
For example, acetic acid is a weak acid which has a = 1.75 x 10 −5. Its conjugate base is the acetate ion with K b = 10 −14 /K a = 5.7 x 10 −10 (from the relationship K a × K b = 10 −14), which certainly does not correspond to a strong base. The conjugate of a weak acid is often a weak base and vice versa.
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