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  2. G-quadruplex - Wikipedia

    en.wikipedia.org/wiki/G-quadruplex

    Identifying and predicting sequences which have the capacity to form quadruplexes is an important tool in further understanding their role. Generally, a simple pattern match is used for searching for possible intrastrand quadruplex forming sequences: d(G 3+ N 1-7 G 3+ N 1-7 G 3+ N 1-7 G 3+), where N is any nucleotide base (including guanine). [78]

  3. Guanine tetrad - Wikipedia

    en.wikipedia.org/wiki/Guanine_tetrad

    [1] [2] They most prominently contribute to the structure of G-quadruplexes, where their hydrogen bonding stabilizes the structure. [3] [4] Usually, there are at least two guanine tetrads in a G-quadruplex, and they often feature Hoogsteen-style hydrogen bonding. [1] Guanine tetrads are formed by sequences rich in guanine, such as GGGGC. [5]

  4. Antiparallel (biochemistry) - Wikipedia

    en.wikipedia.org/wiki/Antiparallel_(biochemistry)

    G-quadruplexes, also known as G4 DNA are secondary structures found in nucleic acids that are rich in guanine. [1] These structures are normally located at the telomeres (the ends of the chromosomes). The G-quadruplex can either be parallel or antiparallel depending on the loop configuration, which is a component of the structure.

  5. Non-canonical base pairing - Wikipedia

    en.wikipedia.org/wiki/Non-canonical_base_pairing

    It is possible that these sequence stretches form G-quadruplex like structures, which can suppress the expression of the related genes. The complementary cytosine rich sequences, on the other strand, may adopt another similar four stranded structure, the i-motif, stabilized by cytosine:cytosine non-canonical base pairs.

  6. DNA damage (naturally occurring) - Wikipedia

    en.wikipedia.org/wiki/DNA_damage_(naturally...

    DNA damage is an abnormal chemical structure in DNA, while a mutation is a change in the sequence of base pairs. DNA damages cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly. [1]

  7. Structural motif - Wikipedia

    en.wikipedia.org/wiki/Structural_motif

    An individual motif usually consists of only a few elements, e.g., the 'helix-turn-helix' motif which has just three. Note that, while the spatial sequence of elements may be identical in all instances of a motif, they may be encoded in any order within the underlying gene. In addition to secondary structural elements, protein structural motifs ...

  8. Britney Spears Reveals She Moved to Mexico to Escape ...

    www.aol.com/entertainment/britney-spears-reveals...

    Britney Spears has left the building, announcing on her 43rd birthday that she has moved to Mexico. The pop singer shared the news on Instagram on Monday, saying, “It really kind of hurts my ...

  9. Hoogsteen base pair - Wikipedia

    en.wikipedia.org/wiki/Hoogsteen_base_pair

    Hoogsteen pointed out that if the alternative hydrogen-bonding patterns were present in DNA, then the double helix would have to assume a quite different shape. Hoogsteen base pairs are observed in alternative structures such as the four-stranded G-quadruplex structures that form in DNA and RNA.