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Basophilic stippling, also known as punctate basophilia, is the presence of numerous basophilic granules that are dispersed through the cytoplasm of erythrocytes in a peripheral blood smear. They can be demonstrated to be RNA .
A cell containing Pappenheimer bodies is a siderocyte. Reticulocytes often contain Pappenheimer bodies. They are mostly observed in diseases such as myelodysplastic syndrome (MDS), sideroblastic anemia, hemolytic anemia, lead poisoning and sickle cell disease. They can interfere with platelet counts when the analysis is performed by electro ...
However, basophilic stippling is also seen in unrelated conditions, such as megaloblastic anemia caused by vitamin B12 ... Cases of mass lead poisoning can occur.
With lead poisoning, see coarse basophilic stippling of red blood cells on peripheral blood smear; Specific test: Prussian blue stain of RBC in marrow shows ringed sideroblasts. Prussian blue staining involves a non-enzymatic reaction of ferrous iron with ferrocyanide forming ferric-ferrocyanide, which is blue in color.
Lead poisoning is most commonly caused by breathing in lead dust or particles, but it can also occur by touching a surface where lead is present, then touching one’s nose or mouth, ...
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Rare acquired causes of microcytic anemia include lead poisoning, zinc deficiency, copper deficiency, alcohol, and certain medications. [3] Other causes that are typically thought of as causing normocytic anemia or macrocytic anemia must also be considered, as the presence of two or more causes of anemia can distort the typical picture.
Lead poisoning occurs when lead builds up in the body, often over months or years, according to Mayo Clinic, and even small amounts can cause issues. It's common in adults who do home renovations ...