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Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about three people per million members of the population. [1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. [2]
Cancer Research UK has recently warned that skin cancer cases are set to rise by half by 2040
Merkel cells, also known as Merkel–Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for light touch sensation and found in the skin of vertebrates. They are abundant in highly sensitive skin like that of the fingertips in humans , and make synaptic contacts with somatosensory afferent nerve fibers .
Tissue staining using a monoclonal antibody against MCV T antigen shows utility in differentiating Merkel cell carcinoma from other small, round cell tumors. [78] Blood tests to detect MCV antibodies have been developed and show that infection with the virus is widespread although Merkel cell carcinoma patients have exceptionally higher ...
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Pseudorosettes are present in neuroblastoma, medulloblastoma, malignant melanoma, ependymoma, Merkel cell carcinoma, neuroendocrine tumor of the skin, seborrheic keratosis, dendritic cell neurofibroma, astroblastoma, large cell neuroendocrine tumor of the cervix, clear cell ependymoma of the spinal cord, celiac disease, nasal tumor of olfactory ...
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