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Cutaneous squamous-cell carcinoma (cSCC), also known as squamous-cell carcinoma of the skin or squamous-cell skin cancer, is one of the three principal types of skin cancer, alongside basal-cell carcinoma and melanoma. [10] cSCC typically presents as a hard lump with a scaly surface, though it may also present as an ulcer. [1]
The International Classification of Diseases for Oncology (ICD-O) is a domain-specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. This classification is widely used by cancer registries. It is currently in its third revision (ICD-O-3). ICD-10 includes a list of ...
This often leads to a higher risk of melanoma, a serious type of skin cancer. [10] Dysplastic nevi are more likely than ordinary moles to become cancerous. While dysplastic nevi are common and many people have a few of these abnormal moles, having more than 50 ordinary moles also increases the risk of developing melanoma. [11]
However, a melanocytic nevus is benign, and melanoma is malignant. Most melanocytic nevi never evolve into a cancer, with the lifetime risk for an individual nevus being 1 in 3000 for men and 1 in 11 000 for women. [5] Moreover, dermatologists have a standardized system for determining whether a skin lesion is suspicious for malignant melanoma.
Melanoma is the most dangerous type of skin cancer; it develops from the melanin-producing cells known as melanocytes. [1] It typically occurs in the skin, but may rarely occur in the mouth, intestines, or eye (uveal melanoma). [1] [2] In women, melanomas most commonly occur on the legs; while in men, on the back. [2]
doi: 10.3892/or.19.6.1367. PMID 18497938. Murphy, George F. "Case 12: Melanocytic tumor of uncertain malignant potential (MELTUMP)". In Artur Zembowicz (ed.). Cases in Dermatopathology: Common Problems in Diagnosis of Pigmented Lesions. Los Gatos, California: Knowledge Books and Software. pp. 73– 80. ISBN 1-74162-088-0
Lentigo maligna is where melanocyte cells have become malignant and grow continuously along the stratum basale of the skin, [1] but have not invaded below the epidermis. [2] Lentigo maligna is not the same as lentigo maligna melanoma, as detailed below. It typically progresses very slowly and can remain in a non-invasive form for years.
Typically, between 1000 and 2000 melanocytes are found per square millimeter of skin or approximately 5% to 10% of the cells in the basal layer of epidermis. Although their size can vary, melanocytes are typically 7 μm in length.