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A natural supplement that puts you to sleep? At the same time, the supplement world is notorious for inflated claims, so the hype around melatonin and valerian makes me more than a little skeptical.
Crude extract of valerian root may have sedative and anxiolytic effects, and is commonly sold in dietary supplement capsules to promote sleep, but clinical evidence that it is effective for this purpose is weak or inconclusive. [1] [2] Its roots and leaves cause a catnip-like response in cats.
This serotonin receptor subtype is distributed in the suprachiasmatic nucleus, a tiny brain region implicated in the sleep-wake cycle. [6] A study in 2006 found valerian extract as well as valerenic acid to inhibit NF-κB, a protein complex that controls the transcription of DNA, in HeLa (cultured human cancer) cells.
Valerian: garden valerian, garden heliotrope, all-heal Valeriana officinalis "drowsiness, GI upset, headache, palpitations, insomnia", [3] oversedation, overstimulation [16] Vasambu sweet flag Acorus calamus: Vomiting and nausea [22] Yohimbe: yohimbine Pausinystalia johimbe: rapid heart rate, hypertension, hypotension, heart problems, death [4]
Before adding any new supplement or sleep aid to your nighttime routine, speak with your healthcare provider to make sure it’s safe and appropriate for you. Meeko Media/Istockphoto 6.
This isn’t the first time that better sleep has been linked with a lower risk of dementia: A study published in October even found that people with sleep apnea are more likely to develop dementia.
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