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1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC, EDAC or EDCI) is a water-soluble carbodiimide usually handled as the hydrochloride. [1] It is typically employed in the 4.0-6.0 pH range. It is generally used as a carboxyl activating agent for the coupling of primary amines to yield amide bonds.
Ethacizine (ethacyzine) is a class Ic antiarrhythmic agent, related to moracizine. [2] It is used in Russia and some other CIS countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias, especially those accompanied by organic heart disease.
It has a modest affinity to the 5-HT [1A, 1E, 2B, 7] receptors, and little to no affinity at the 5-HT [2A, 2C, 3, 4, 5A, 6] receptors. Eletriptan has no significant affinity or pharmacological activity at adrenergic α 1, α 2, or β; dopaminergic D 1 or D 2; muscarinic; or opioid receptors. Eletriptan could be efficiently co-administered with ...
The acid 1 will react with the carbodiimide to produce the key intermediate: the O-acylisourea 2, which can be viewed as a carboxylic ester with an activated leaving group. The O-acylisourea will react with amines to give the desired amide 3 and urea 4. The possible reactions of the O-acylisourea 2 produce both desired and undesired products.
Triethylenetetramine (TETA and trien), also known as trientine when used medically, is an organic compound with the formula [CH 2 NHCH 2 CH 2 NH 2] 2.The pure freebase is a colorless oily liquid, but, like many amines, older samples assume a yellowish color due to impurities resulting from air-oxidation.
Tapentadol, sold under the brand names Nucynta and Palexia among others, is a synthetic opioid analgesic of the benzenoid class with a dual mode of action as a highly selective full agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI). [7]
Rilmazafone [1] (リスミー, Rhythmy, previously known as 450191-S) is a water-soluble prodrug developed in Japan. [2] Inside the human body, rilmazafone is converted into several benzodiazepine metabolites that have sedative and hypnotic effects. [3] [4] [5]
ethyl 3-oxo-4-phenylbutanoate phenylacetone: ethyl-3-(1,3-benzodioxol-5-yl)-2-methyloxirane-2-carboxylate (MDP2P ethyl glycidate) MDMA: Formamide: amphetamine, methamphetamine Formic acid: amphetamine, methamphetamine Lithium aluminum hydride: amphetamine, methamphetamine Lithium metal amphetamine, methamphetamine Magnesium metal (turnings ...
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