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Polycythemia in newborns is defined as hematocrit > 65%. Significant polycythemia can be associated with blood hyperviscosity, or thickening of the blood. Causes of neonatal polycythemia include: Hypoxia: Poor oxygen delivery (hypoxia) in utero resulting in compensatory increased production of red blood cells (erythropoeisis). Hypoxia can be ...
Red blood cell distribution width (RDW), as well as various types thereof (RDW-CV or RCDW and RDW-SD), is a measure of the range of variation of red blood cell (RBC) volume that is reported as part of a standard complete blood count. [1] Red blood cells have an average volume of 80–100 femtoliters, but individual cell volumes vary even in ...
The first is a very high red blood cell count, which is usually identified by elevated levels of hemoglobin or hematocrit; A bone marrow biopsy that shows hypercellularity and abnormalities in megakaryocytes; and; The presence of a mutation in the Janus kinase 2 (JAK2) gene.
This phenomenon causes red blood cells to clump together because of antibodies bound to the cell surface. [196] Red blood cell aggregates are counted as single cells by the analyzer, leading to a markedly decreased red blood cell count and hematocrit, and markedly elevated MCV and MCHC (mean corpuscular hemoglobin concentration). [53]
As a result, the contents of the red blood cell are released into the general circulation, leading to hemoglobinemia [31] and increasing the risk of ensuing hyperbilirubinemia. [32] Intravascular hemolysis may occur when red blood cells are targeted by autoantibodies, leading to complement fixation, or by damage by parasites such as Babesia. [33]
The spherocytes create variation in the size of the red blood cells on average, thus expanding the distribution. Red blood cell count (RBC): Sometimes increased early (normal range males: 4.3–5.9 million/mm 3; normal range females: 3.5–5.5 million/mm 3). The loss of surface area per cells cause the body to mass produce red blood cells.
A low reticulocyte count would signify there is a problem at the level of the bone marrow, which produce the stem cells. Acute blood loss would result in a high reticulocyte count, as bone marrow processes are normal and the bone marrow responds accordingly to the body's need for blood.
Anisocytosis is a medical term meaning that a patient's red blood cells are of unequal size. This is commonly found in anemia and other blood conditions. False diagnostic flagging may be triggered on a complete blood count by an elevated WBC count, agglutinated RBCs, RBC fragments, giant platelets or platelet clumps due to anisocytosis.
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