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Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. [1] The effect is most studied with grapefruit and grapefruit juice, [1] but similar effects have been observed with certain other citrus fruits.
In addition, grapefruit can have the opposite effect on certain antihistamines, such as Allegra. These allergy medicines are absorbed into our body's cells through proteins known as transporters.
Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
Grapefruit juice contains bergamottin, one of the furanocoumarins which inhibit the metabolism of many drugs, causing multiple side-effects. [19] Grapefruit and grapefruit juice interact with numerous drugs, resulting in numerous adverse effects including bone marrow suppression, nephrotoxicity, abnormal heart rhythm, rhabdomyolysis ...
While grapefruit consumption may seem harmless, you may actually experience heightened side effects of Cialis. Tadalafil and grapefruit may not produce noticeable side effects in smaller amounts ...
Other side effects, such as dyspepsia and back pain, were also reported less frequently by men prescribed Cialis for daily use. ... Grapefruit juice can be a problem too. If you want to take ...
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...
One major concern is that grapefruit can interact with certain medications, including some statins and anti-anxiety drugs, leading to dangerous side effects. Grapefruit contains compounds that can ...