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  2. Uremia - Wikipedia

    en.wikipedia.org/wiki/Uremia

    Uremia is the condition of having high levels of urea in the blood. Urea is one of the primary components of urine.It can be defined as an excess in the blood of amino acid and protein metabolism end products, such as urea and creatinine, which would normally be excreted in the urine.

  3. Hyperuricemia - Wikipedia

    en.wikipedia.org/wiki/Hyperuricemia

    Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [5] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...

  4. Fanconi syndrome - Wikipedia

    en.wikipedia.org/wiki/Fanconi_syndrome

    Fanconi syndrome or Fanconi's syndrome (English: / f ɑː n ˈ k oʊ n i /, / f æ n-/) is a syndrome of inadequate reabsorption in the proximal renal tubules [1] of the kidney.The syndrome can be caused by various underlying congenital or acquired diseases, by toxicity (for example, from toxic heavy metals), or by adverse drug reactions. [2]

  5. Protein toxicity - Wikipedia

    en.wikipedia.org/wiki/Protein_toxicity

    Protein toxicity is the effect of the buildup of protein metabolic waste compounds, like urea, uric acid, ammonia, and creatinine.Protein toxicity has many causes, including urea cycle disorders, genetic mutations, excessive protein intake, and insufficient kidney function, such as chronic kidney disease and acute kidney injury.

  6. Ornithine translocase deficiency - Wikipedia

    en.wikipedia.org/wiki/Ornithine_translocase...

    Ornithine translocase deficiency belongs to a class of metabolic disorders referred to as urea cycle disorders. The urea cycle is a sequence of reactions that occurs in liver cells. This cycle processes excess nitrogen, generated when protein is used by the body, to make a compound called urea that is excreted by the kidneys.

  7. Urea cycle - Wikipedia

    en.wikipedia.org/wiki/Urea_cycle

    The urea cycle converts highly toxic ammonia to urea for excretion. [1] This cycle was the first metabolic cycle to be discovered by Hans Krebs and Kurt Henseleit in 1932, [2] [3] [4] five years before the discovery of the TCA cycle. The urea cycle was described in more detail later on by Ratner and Cohen.

  8. Citrullinemia - Wikipedia

    en.wikipedia.org/wiki/Citrullinemia

    Citrullinemia is an autosomal recessive urea cycle disorder that causes ammonia and other toxic substances to accumulate in the blood. [1] Two forms of citrullinemia have been described, both having different signs and symptoms, and are caused by mutations in different genes. Citrullinemia belongs to a class of genetic diseases called urea ...

  9. Polyuria - Wikipedia

    en.wikipedia.org/wiki/Polyuria

    The most common cause of polyuria in both adults and children is uncontrolled diabetes mellitus, [6] which causes osmotic diuresis; when glucose levels are so high that glucose is excreted in the urine. Water follows the glucose concentration passively, leading to abnormally high urine output.