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The biosynthesis of the tropane alkaloids have attracted intense interest because of their high physiological activity as well as the presence of the bicyclic tropane core. [12] Final stages in the pathway for the biosynthesis of the tropane alkaloid cocaine.
Cocaine (from French cocaïne, from Spanish coca, ultimately from Quechua kúka) [13] is a tropane alkaloid that acts as a central nervous system (CNS) stimulant. As an extract, it is mainly used recreationally and often illegally for its euphoric and rewarding effects.
Of the approximately 200 members in the genus Erythroxylum, most species contain the central nervous system stimulant tropane alkaloid, known more commonly as cocaine.Because the plant is endemic ...
Tropane is a nitrogenous bicyclic organic compound. It is mainly known for the other alkaloids derived from it, which include atropine and cocaine , among others. Tropane alkaloids occur in plants of the families Erythroxylaceae (including coca ) and Solanaceae (including mandrake , henbane , deadly nightshade , datura , potato , tomato ).
Chemical structure of cocaine. The biosynthesis of cocaine has long attracted the attention of biochemists and organic chemists. This interest is partly motivated by the strong physiological effects of cocaine, but a further incentive was the unusual bicyclic structure of the molecule. The biosynthesis can be viewed as occurring in two phases ...
Ecgonine (tropane derivative) is a tropane alkaloid found naturally in coca leaves. It has a close structural relation to cocaine: it is both a metabolite and a precursor, and as such, it is a controlled substance in many jurisdictions, as are some substances which can be used as precursors to ecgonine itself.
The term may also be loosely used to refer to drugs manufactured from cocaine or having their basis as a total synthesis of cocaine, but modified to alter their effect & QSAR. These include both intracellular sodium channel blocker anaesthetics and stimulant dopamine reuptake inhibitor ligands (such as certain, namely tropane-bridged-excised ...
Coca alkaloids are the alkaloids found in the coca plant, Erythroxylum coca. [1] They are predominantly of either the pyrrolidine or the tropane types. Tropane-type alkaloids