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Cocaine — a tropane alkaloid — is a weakly alkaline compound, and can therefore combine with acidic compounds to form salts. The hydrochloride (HCl) salt of cocaine is by far the most commonly encountered, although the sulfate (SO 4 2− ) and the nitrate (NO 3 − ) salts are occasionally seen.
Tropane alkaloids occur naturally in many members of the plant family Solanaceae. Certain tropane alkaloids such as cocaine and scopolamine are notorious for their psychoactive effects, related usage and cultural associations.
Of the approximately 200 members in the genus Erythroxylum, most species contain the central nervous system stimulant tropane alkaloid, known more commonly as cocaine.Because the plant is endemic ...
Ecgonine (tropane derivative) is a tropane alkaloid found naturally in coca leaves. It has a close structural relation to cocaine: it is both a metabolite and a precursor, and as such, it is a controlled substance in many jurisdictions, as are some substances which can be used as precursors to ecgonine itself.
RTI-336 is an interesting example of a phenyltropane that is being explored in the context of a treatment for cocaine addiction. [14] RTI-336 is a DRI and thus specifically targets the DAT which is responsible for the addictive properties of cocaine.
RTI(-4229)-113 (2β-carbophenoxy-3β-(4-chlorophenyl)tropane) is a stimulant drug which acts as a potent and fully selective dopamine reuptake inhibitor (DRI). It has been suggested as a possible substitute drug for the treatment of cocaine addiction .
Tropane is a nitrogenous bicyclic organic compound. It is mainly known for the other alkaloids derived from it, which include atropine and cocaine , among others. Tropane alkaloids occur in plants of the families Erythroxylaceae (including coca ) and Solanaceae (including mandrake , henbane , deadly nightshade , datura , potato , tomato ).
Methylecgonine, also known as ecgonine methyl ester is a prominent tropane alkaloid found in coca leaves. [1] It is metabolite of cocaine, [2] and may be used as a precursor for it. It also occurs as minor alkaloid in roots of many Datura species such as Datura stramonium [3] and Datura innoxia. [4]
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