Search results
Results from the WOW.Com Content Network
Radial glial cells, or radial glial progenitor cells (RGPs), are bipolar-shaped progenitor cells that are responsible for producing all of the neurons in the cerebral cortex. RGPs also produce certain lineages of glia , including astrocytes and oligodendrocytes .
In the mature brain, the cerebellum and retina retain characteristic radial glial cells. In the cerebellum, these are Bergmann glia , which regulate synaptic plasticity . In the retina, the radial Müller cell is the glial cell that spans the thickness of the retina and, in addition to astroglial cells, [ 16 ] participates in a bidirectional ...
Studies have shown that radial glia in the SGZ express nestin and Sox2, biomarkers associated with neural stem cells, and that isolated radial glia can generate new neurons in vitro. [8] Radial glial cells often divide asymmetrically, producing one new stem cell and one neuronal precursor cell per division. Thus, they have the capacity for self ...
The Radial Unit Hypothesis (RUH) is a conceptual theory of cerebral cortex development, first described by Pasko Rakic. It states that the cerebral cortex develops during embryogenesis as an array of interacting cortical columns , or 'radial units', each of which originates from a transient stem cell layer called the ventricular zone , which ...
Many of the neuroepithelial cells also divide into radial glial cells, a similar, but more fate restricted cell. Being a more fate restricted cell the radial glial cell will either generate postmitotic neurons, intermediate progenitor cells, or astrocytes in gliogenesis. During neuroepithelial cell division, interkinetic nuclear migration ...
Radial glial cells, also called radial glial progenitor cells, divide asymmetrically to produce a neuroblast and another radial glial cell that will re-enter the cell cycle. [5] [3] This mitosis occurs in the germinal neuroepithelium (or germinal zone), when a radial glial cell divides to produce the neuroblast. The neuroblast detaches from the ...
The MGE also produces some of the neurons and glia of the basal ganglia and hippocampus. [ 6 ] [ 7 ] The MGE may also be a source of Cajal-Retzius cells, but this remains controversial. [ 6 ] Early in embryonic development, the interneurons in the cortex stem primarily from the MGE [ 8 ] and the AEP.
In vertebrates, the ventricular zone (VZ) is a transient embryonic layer of tissue containing neural stem cells, principally radial glial cells, of the central nervous system (CNS). [1] [2] The VZ is so named because it lines the ventricular system, which contains cerebrospinal fluid (CSF).