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One of the most prevalent forms of adverse drug reactions is cutaneous reactions, [1] with drug-induced urticaria ranking as the second most common type, preceded by drug-induced exanthems. [2] Urticaria, commonly known as hives , manifests as weals, itching, burning, redness, swelling, and angioedema —a rapid swelling of lower skin layers ...
A drug allergy is an allergy to a drug, most commonly a medication, and is a form of adverse drug reaction. Medical attention should be sought immediately if an allergic reaction is suspected. An allergic reaction will not occur on the first exposure to a substance.
Solar urticaria is an immunoglobulin E-mediated hypersensitivity that can be introduced through primary or secondary factors, or induced by exogenous photosensitization. [15] [16] Primary SU is believed to be a type I hypersensitivity (a mild to severe reaction to an antigen including anaphylaxis) in which an antigen, or substance provoking an immune response, is "induced by UV or visible ...
Dermatographic urticaria is sometimes called "skin writing", as it is possible to mark deliberate patterns onto the skin. The condition manifests as an allergic-like reaction, causing a warm red wheal to appear on the skin. As it is often the result of scratches, involving contact with other materials, it can be confused with an allergic ...
Urticaria pigmentosa (also known as generalized eruption of cutaneous mastocytosis (childhood type) [1]: 616 ) is the most common form of cutaneous mastocytosis. It is a rare disease caused by excessive numbers of mast cells in the skin that produce hives or lesions on the skin when irritated.
Chronic spontaneous urticaria, despite its cause being unknown, is linked to a higher prevalence of autoimmune diseases, and is often worsened by triggers like stress, infections, certain foods, or nonsteroidal anti-inflammatory drugs. The hives and angioedema seen in CSU is thought to be linked to the degranulation of skin mast cells.
Hives, also known as urticaria, is a kind of skin rash with red and/or flesh-colored, raised, itchy bumps. [1] Hives may burn or sting. [ 2 ] The patches of rash may appear on different body parts, [ 2 ] with variable duration from minutes to days, and do not leave any long-lasting skin change. [ 2 ]
Remibrutinib is a small molecule drug that acts as a Bruton's tyrosine kinase (BTK) inhibitor. It is in development for the treatment of chronic spontaneous urticaria. [1] [2] In November 2023, Novartis announced that the compound "demonstrated clinically meaningful and statistically significant reduction in urticaria activity vs placebo" in a Phase III trial.