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The CTCAE system is a product of the US National Cancer Institute (NCI). The first Iteration was prior to 1998. In 1999, the FDA released version 2.0. CTCAE version 4.0 in 2009 with an update to y version 4.03 in 2010. [2] The current version 5.0 was released on November 27, 2017.
The term genome was created in 1920 by Hans Winkler, [8] professor of botany at the University of Hamburg, Germany.The website Oxford Dictionaries and the Online Etymology Dictionary suggest the name is a blend of the words gene and chromosome.
In 2019, the U.S. Bureau of Economic Analysis valued the gross domestic product (GDP) of the Buffalo–Niagara Falls MSA at $53 billion (~$62.3 billion in 2023). [ 131 ] The civic sector is a major source of employment in the Buffalo area, and includes public, non-profit, healthcare and educational institutions. [ 132 ]