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A human chimera is a human with a subset of cells with a distinct genotype than other cells, that is, having genetic chimerism.In contrast, an individual where each cell contains genetic material from a human and an animal is called a human–animal hybrid, while an organism that contains a mixture of human and non-human cells would be a human-animal chimera.
Two-colored rose chimera. A genetic chimerism or chimera (/ k aɪ ˈ m ɪər ə / ky-MEER-ə or / k ɪ ˈ m ɪər ə / kim-EER-ə) is a single organism composed of cells with more than one distinct genotype. Animal chimeras can be produced by the merger of two (or more) embryos.
Diagnosing a chimera or mosaic is particularly difficult due to the random distribution of 46,XX and 46,XY cells within the body. In a chimeric, an organ might be made up of a mix of 46,XX and 46,XY, but is made up entirely only one genotype. When that is the case, no abnormalities are noted and other types of tissues need to be analyzed. [15]
In molecular biology, and more importantly high-throughput DNA sequencing, a chimera is a single DNA sequence originating when multiple transcripts or DNA sequences get joined. Chimeras can be considered artifacts and be filtered out from the data during processing [ 1 ] to prevent spurious inferences of biological variation. [ 2 ]
It can occur in all kinds of species, including, very rarely in humans. Chimeras were named for a mythological monster that was a combination of several different animals.
This can also be seen in the different hieroglyphs that could be used to write the name of a single deity. Other notable examples include: Horus features the head of a falcon. Anubis has a jackal's head. Set, often depicted with the head of an unknown creature, gets associated with a being referred to as the "Set animal" by Egyptologists.
According to Catster, "A chimera cat results from two embryos merging in their mother’s womb in the early stages of development. This results in a single cat carrying two sets of DNA instead of one.
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