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Members of the Argonaute (Ago) protein family are central to RISC function. Argonautes are needed for miRNA-induced silencing and contain two conserved RNA binding domains: a PAZ domain that can bind the single stranded 3' end of the mature miRNA and a PIWI domain that structurally resembles ribonuclease-H and functions to interact with the 5 ...
Function Distribution Ref. Small nuclear RNA: snRNA: Splicing and other functions: Eukaryotes and archaea [3] Small nucleolar RNA: snoRNA: Nucleotide modification of RNAs: Eukaryotes and archaea [4] SmY RNA: SmY: mRNA trans-splicing: Nematodes [5] Small Cajal body-specific RNA: scaRNA: Type of snoRNA; Nucleotide modification of RNAs: Guide RNA ...
This suggests the possibility of a relation between the miRNA and the disease. It is also suggested that the endogenous expression of the Bantam gene in the developing eye imaginal disc contributes to controlling the level of hid-induced apoptosis, which is normally involved in reducing cell number in the pupal eye disc.
miR-92 is part of a large precursor sequence that forms a stem loop once transcribed into RNA. This long precursor sequence is a component of the mir-17-92 cluster which contains 5 additional mir precursor sequences: mir-17, mir-18a, mir-19a, mir-20a and mir19b-1. [4]
The mature miRNA of miR-26a-1 and miR-26a-2 possesses the same sequence, with the exception of 2 different nucleotides in mature miR-26b. [ 2 ] miR-26 appears to be a vertebrate specific microRNA [ 3 ] [ 4 ] and has now been predicted or experimentally validated in many vertebrate species ( MIPF0000043 ).
n/a Ensembl ENSG00000284190 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 17: 59.84 – 59.84 Mb n/a PubMed search n/a Wikidata View/Edit Human microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene. MIRN21 was one of the first mammalian microRNAs identified. The mature miR-21 sequence is strongly ...
Label-free miRNA biosensors were initially based on DNA detection through guanine electrooxidation measurements, with the lower detection limit being 5 nM of miRNA. Since then, electrode materials have been developed to increase the sensitivity of detection down to less than 1 pM, such as with graphene and ionic-liquid modified electrodes.
n/a Ensembl ENSG00000199085 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 7: 25.95 – 25.95 Mb n/a PubMed search n/a Wikidata View/Edit Human MicroRNA 148a is a miRNA that in humans is encoded by the MIR148A gene. Function microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in ...