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Hyperpigmentation is believed to be related to the enzyme tyrosinase which produces melanin. Among several chemicals known to inhibit tyrosinase production, such as hydroquinone , arbutin , and kojic acid , 4-butylresorcinol has been found to be the most powerful inhibitor by a wide margin.
Decreasing tyrosinase activity has been targeted for the improvement or prevention of conditions related to the hyperpigmentation of the skin, such as melasma and age spots. [ 22 ] Several polyphenols, including flavonoids or stilbenoid , substrate analogues, free radical scavengers, and copper chelators, have been known to inhibit tyrosinase ...
This toner takes skin-brightening to the next level by pairing kojic acid with vitamin C — yet another tyrosinase inhibitor — as well as bearberry extract, a plant-based alternative to ...
These nine foods deliver filling fiber and protein while being lower in calories—a combination that makes it easier to lose weight without feeling deprived. Read on to learn more about these ...
Several skin whitening agents, including tyrosinase inhibitors, have been found to cause an increase in the expression of tyrosinase, which by itself would increase melanin synthesis. [ 41 ] Microphthalmia-associated transcription factor (MITF) is the master transcription factor that controls the expression of TYR, TRP1, and TRP2, MART1 ...
One study found that, when added to shower gel formulations, three different mushroom extracts—maitake, reishi, and lion's mane—helped to reduce transepidermal water loss (TEWL).
α-Arbutin directly inhibits the enzymatic activity of tyrosinase, which is essential for melanin synthesis. Tyrosinase catalyzes the first two steps in melanin production: the hydroxylation of tyrosine to l-DOPA and the oxidation of l-DOPA to dopaquinone. By inhibiting tyrosinase, α-arbutin reduces the formation of melanin in melanocytes. [5]
Plus, research links high-fiber foods to weight loss and an all-around healthy diet. Additionally, cruciferous veggies are jam-packed with vitamins, minerals, and antioxidants, supporting overall ...
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