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Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B 1). [1] A severe and chronic form is known as beriberi. [1] [7] The name beriberi was possibly borrowed in the 18th century from the Sinhalese phrase බැරි බැරි (bæri bæri, “I cannot, I cannot”), owing to the weakness caused by the condition.
Thiamine, also known as thiamin and vitamin B 1, is a vitamin, an essential micronutrient for humans and animals. [3] [4] It is found in food and commercially synthesized to be a dietary supplement or medication. [1] [5] Phosphorylated forms of thiamine are required for some metabolic reactions, including the breakdown of glucose and amino ...
Thiamine (vitamin B 1) is an essential coenzyme in carbohydrate metabolism and is also a regulator of osmotic gradient. Its deficiency may cause swelling of the intracellular space and local disruption of the blood-brain barrier. Brain tissue is very sensitive to changes in electrolytes and pressure and edema can be cytotoxic.
Wernicke encephalopathy (WE), also Wernicke's encephalopathy, [1] or wet brain is the presence of neurological symptoms caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B 1). [2]
Dietary supplements containing all eight are referred to as a vitamin B complex. Individual B vitamins are referred to by B-number or by chemical name, such as B 1 for thiamine , B 2 for riboflavin , and B 3 for niacin , [ 1 ] [ 2 ] while some are more commonly recognized by name than by number, such as pantothenic acid (B 5 ), biotin (B 7 ...
Vitamin B 1 analogues are analogues of vitamin B 1, thiamine. They typically have improved bioavailability relative to thiamine itself, and are used to treat conditions caused by vitamin B 1 deficiency. These conditions include beriberi, Korsakoff's syndrome, Wernicke's encephalopathy and diabetic neuropathy.
An individual's nutritional intake also plays a role in the development of this disease. Depending on the specific dietary habits, they may have a deficiency of one or more of the following: thiamine (vitamin B1), niacin (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (vitamin B6) and biotin (vitamin B7), vitamin B12, folic acid, and ...
Haff disease is the development of rhabdomyolysis (swelling and breakdown of skeletal muscle, ... (i.e. it degrades thiamine, also known as vitamin B1). [12]
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