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Michael F. Holick (/ ˈ h ɒ l ɪ k / HOLL-ik; [1] born 1946) is an American adult endocrinologist, specializing in vitamin D, such as the identification of both calcidiol, the major circulating form of vitamin D, and calcitriol, the active form of vitamin D. His work has been the basis for diagnostic tests and therapies for vitamin D-related ...
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Calcifediol is strongly bound in blood by the vitamin D-binding protein. [5] Measurement of serum calcifediol is the usual test performed to determine a person's vitamin D status, to show vitamin D deficiency or sufficiency. [4] [5] Calcifediol is available as an oral medication in some countries to supplement vitamin D status. [4] [6] [7]
These two forms of vitamin D are metabolized in the liver and stored as 25-hydroxyvitamin D. [4] Before biological use, the storage form must be converted into an active form. One common active form is 1,25-dihydroxyvitamin D. [4] The term vitamin D in this article means cholecalciferol, ergocalciferol, 25-hydroxyvitamin D, and the active forms ...
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