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2. Direct factor Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

   Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...

3. Rivaroxaban - Wikipedia

   en.wikipedia.org/wiki/Rivaroxaban

   Rivaroxaban bears a striking structural similarity to the antibiotic linezolid: both drugs share the same oxazolidinone-derived core structure. [39] Accordingly, rivaroxaban was studied for any possible antimicrobial effects and for the possibility of mitochondrial toxicity , which is a known complication of long-term linezolid use. [ 40 ]

4. The 17 Most Common Pet Health Issues Will Set You Back This Much

   www.aol.com/17-most-common-pet-health-155800128.html

   Bloat or GDV/Gastropexy. Approximate Cost: $1,500 - $7,500. Bloat, or Gastric Dilatation-Volvulus (GDV), is a life-threatening condition where a dog’s stomach twists and becomes distended.

5. 15 Most Common Puppy Health Issues and How to Spot Them - AOL

   www.aol.com/15-most-common-puppy-health...

   External Parasites. The second most common problem in most places is fleas. If there are just a few, they can be taken off with a flea comb a few times a day.

6. 7 Alternatives to Chemotherapy for Lymphoma in Dogs - AOL

   www.aol.com/7-alternatives-chemotherapy-lymphoma...

   1. Ketogenic Diet. Cancer cells rely on glucose for energy to grow. The ketogenic diet is a way to provide an alternative energy source to normal cells in the dog's body while starving the cancer ...

7. Anticoagulant - Wikipedia

   en.wikipedia.org/wiki/Anticoagulant

   An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. [1] Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which help keep the bite area unclotted long enough for the animal to obtain blood.

8. Discovery and development of direct Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   The amino acids residues Phe-174, Tyr-99, and Trp-215 form a narrow hydrophobic channel that is the S4 binding pocket. The morpholinone part of rivaroxaban is “sandwiched” between amino acids Tyr-99 and Phe-174 and the aryl ring of rivaroxaban is oriented perpendicularly across Trp-215. The morpholinone carbonyl group does not have a direct ...

9. Popular dog arthritis medication Librela linked to pet ... - AOL

   www.aol.com/popular-dog-arthritis-medication...

   More than 3,600 cases of debilitating dog health problems caused by the medication were reported between January 2023 and March 2024, the FDA said in the cautionary letter, published Monday.