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Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...
The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox). This amino acid sequence folds into a "helix-turn-helix" (i.e. homeodomain fold) motif that is stabilized by a third helix.
Rax (Retina and Anterior Neural Fold Homeobox) is a gene in the OAR (Otx, Arx,& Rax) subgroup of the paired-like homeodomain family of transcription factors. Discovered in 1997, [8] the Rax gene is known to contribute to the development of the retina, hypothalamus, pineal gland and pituitary gland. [9]
The di-helical helix-turn-helix motif is the simplest helix-turn-helix motif. A fragment of Engrailed homeodomain encompassing only the two helices and the turn was found to be an ultrafast independently folding protein domain. [9]
NOBOX belongs to the family of proteins that contains homeodomain. Homeodomain is a stretch of 32 specific amino acids in primates downstream the NOBOX Arg303 residue and is very well-conserved among the species. [11] It contains an asparagine residue at position 51 which is important for its interactions with DNA base pairs. [12] [13] [14]
15433 Ensembl ENSG00000128714 ENSMUSG00000001819 UniProt P35453 P70217 RefSeq (mRNA) NM_000523 NM_008275 RefSeq (protein) NP_000514 NP_032301 Location (UCSC) Chr 2: 176.09 – 176.1 Mb Chr 2: 74.5 – 74.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene. This gene belongs to the homeobox family of ...
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts.
Folding@home (FAH or F@h) is a ... and some forms of the engrailed homeodomain: ... However it was eclipsed by K computer in November 2011 and Blue Gene/Q in June 2012.