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8697 52563 Ensembl ENSG00000094880 ENSMUSG00000024370 UniProt Q9UJX2 Q8BGZ4 RefSeq (mRNA) NM_004661 NM_178347 RefSeq (protein) NP_004652 NP_848124 Location (UCSC) Chr 5: 138.19 – 138.21 Mb Chr 18: 34.76 – 34.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 ...
The cyc gene is located on the left arm of chromosome 3 and codes for a transcription factor containing a basic helix–loop–helix (bHLH) domain and a PAS domain. [1] The 2.17 kb cyc gene is divided into 5 coding exons totaling 1,625 base pairs which code for 413 aminos acid residues.
66214 Ensembl ENSG00000102760 ENSMUSG00000022018 UniProt Q9H4X1 Q9DBX1 RefSeq (mRNA) NM_014059 NM_025427 RefSeq (protein) NP_054778 NP_079703 Location (UCSC) Chr 13: 41.46 – 41.47 Mb Chr 14: 79.53 – 79.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Regulator of cell cycle RGCC (RGCC) also known as response gene to complement 32 protein (RGC-32) is a protein that in humans is ...
CIP/KIP family proteins bind a wide range of G1/S and S-phase cyclin-CDK complexes including cyclin D-CDK4,6 and cyclin E-, A-CDK2 complexes. Traditionally it was assumed that CIP/KIP proteins played a role in inhibiting all of these complexes; however it was later discovered that CIP/KIP proteins, while inhibiting CDK2 activity, may also activate cyclin D-CDK4,6 activity by facilitating ...
As in the mitotic cycle, these transitions are regulated by combinations of different gene regulatory factors, the cyclin-Cdk complex and the anaphase-promoting complex (APC). [1] The first major regulatory transition occurs in late G1 , when the start of meiotic cycle is activated by Ime1 instead of Cln3/Cdk1 in mitosis.
898 12447 Ensembl ENSG00000105173 ENSMUSG00000002068 UniProt P24864 Q61457 RefSeq (mRNA) NM_001238 NM_057182 NM_001322259 NM_001322261 NM_001322262 NM_007633 RefSeq (protein) NP_001229 NP_001309188 NP_001309190 NP_001309191 NP_001309188.1 NP_001309190.1 NP_031659 Location (UCSC) Chr 19: 29.81 – 29.82 Mb Chr 7: 37.8 – 37.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse G1/S ...
67177 Ensembl ENSG00000167513 ENSMUSG00000006585 UniProt Q9H211 Q8R4E9 RefSeq (mRNA) NM_030928 NM_026014 RefSeq (protein) NP_112190 NP_080290 Location (UCSC) Chr 16: 88.8 – 88.81 Mb Chr 8: 123.29 – 123.3 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CDT1 (Chromatin licensing and DNA replication factor 1) is a protein that in humans is encoded by the CDT1 gene. It is a licensing ...
In these cases where the G 1 phase is affected, it is generally because gene regulatory proteins of the E2F family have become unrestrained and increase G 1 /S cyclin gene expression, leading to uncontrolled cell-cycle entry. [2] However, the cure for some forms of cancer also lies in the G 1 phase of the cell cycle.