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Grapiprant is widely accepted in veterinary medicine due to its specific and targeted approach to pain management in dogs. The serum concentration of grapiprant is increased when used in conjunction with other drugs such as acetaminophen, albendazole, and alitretinoin. [citation needed]
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Pet owners who give their dogs homemade diets may incorporate extra vitamins and supplements. Between approximately 10 and 30 percent of dogs in the United States receive nutritional supplements. [70] A survey of U.S. pet owners in 2006 found that the most commonly used supplements were multivitamins and chondroprotective agents. [71]
Another study examined both the serum and the joint synovial fluid after nasogastric (oral) or intravenous administration of 20 mg/kg glucosamine hydrochloride to eight adult horses. [48] Although joint fluid concentrations of glucosamine reached 9–15 μmol/L following intravenous dosing, it was only 0.3–0.7 μmol/L with nasogastric dosing.
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