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3659 16362 Ensembl ENSG00000125347 ENSMUSG00000018899 UniProt P10914 P15314 RefSeq (mRNA) NM_002198 NM_001159393 NM_001159396 NM_008390 RefSeq (protein) NP_002189 NP_001341853 NP_001341854 NP_001152865 NP_001152868 NP_032416 Location (UCSC) n/a Chr 11: 53.66 – 53.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon regulatory factor 1 is a protein that in humans is encoded ...
Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). [1] Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. [2]
IRF3 is a member of the interferon regulatory transcription factor (IRF) family. [5] IRF3 was originally discovered as a homolog of IRF1 and IRF2.IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. [6]
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[7] [8] [9] NF-κB, IRF1, and IRF3 are transcription factors and play critical roles in the production of cytokines. Cellular mechanisms of MAVS pathway. At a resting state for the cell, a protein called mitofusin 2 (MFN2) is known to interact with MAVS, preventing MAVS from binding to the cytosolic proteins, such as RIG-I and MDA5.
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IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. [8] [9] In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, lipopolysaccharide (LPS), IL-4, and CD40.
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation.