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T RM cells develop from circulating effector memory T cell precursors in response to antigen. The main role in formation of T RM cells has CD103 and expression of this integrin is dependent on the cytokine TGF-β. CD8 + effector T cells that lack TGF-β fail to upregulate CD103, and subsequently do not differentiate into T RM cells.
Print/export Download as PDF; ... (IATA code TRM) Science and technology ... T RM cell or tissue-resident memory T cell, in biology; See also
Antigen-presenting cells (APCs) of the thymus, namely medullary thymic epithelial cells (mTECs), dendritic cells (DCs) and B cells are capable to present peptides derived from TRAs to developing T cells (thymus is the major origin of T cell development [3]) and hereby test, whether their T cell receptors (TCRs) engage self entities and ...
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Subsequently, the primed cells will differentiate either into effector cells or into memory cells that can mount stronger and faster response to second and upcoming immune challenges. [2] T and B cell priming occurs in the secondary lymphoid organs (lymph nodes and spleen). Priming of naïve T cells requires dendritic cell antigen presentation.
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Whole-cell pertussis vaccine stimulates natural infection better than the acellular pertussis vaccine. [4] [5]Even though cell-mediated immunity persists in patients received with the acellular pertussis vaccine, stronger lymphocytic proliferation, specifically memory T helper 1 cell and T helper 17 cells and cytokine responses are observed in patients received with the whole cell pertussis ...