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The epidermis is the outermost of the three layers that comprise the skin, the inner layers being the dermis and hypodermis. [1] The epidermis layer provides a barrier to infection from environmental pathogens [2] and regulates the amount of water released from the body into the atmosphere through transepidermal water loss.
A failure to correctly regulate these processes leads to skin disorders developing. [4] Cells of the stratum corneum contain a dense network of keratin, a protein that helps keep the skin hydrated by preventing water evaporation. These cells can also absorb water, further aiding in hydration. In addition, this layer is responsible for the ...
As they are water-soluble themselves, excessive water contact may leach them and inhibit their normal functions which is why prolonged contact with water makes the skin drier. [14] The intercellular lipid layer helps prevent the loss of natural moisturizing factor by sealing the outside of each corneocyte.
It forms the outermost layer of the skin and the inner lining of the mouth, esophagus and vagina. [2] In the epidermis of skin in mammals, reptiles, and birds, the layer of keratin in the outer layer of the stratified squamous epithelial surface is named the stratum corneum. Stratum corneum is made up of squamous cells which are keratinized and ...
Scale forms on the skin surface in various disease settings, and is the result of abnormal desquamation. In pathologic desquamation, such as that seen in X-linked ichthyosis, the stratum corneum becomes thicker (hyperkeratosis), imparting a "dry" or scaly appearance to the skin, and instead of detaching as single cells, corneocytes are shed in clusters, which forms visible scales. [2]
Individuals prone to dry skin or skin sloughing may use a number of methods to prevent the condition in the first place. Decreasing exposure to harsh environments can decrease dry, peeling skin. Avoid extreme heat: Showering or bathing should be done with warm water as opposed to hot. Additionally, heaters and fires produce dry heat.
Basal cells in the basal layer (stratum basale) of the skin are sometimes referred to as basal keratinocytes. [2] Keratinocytes form a barrier against environmental damage by heat , UV radiation , water loss , pathogenic bacteria , fungi , parasites , and viruses .
Next is the dermis, a 3-5 mm thick layer made up of fibrous proteins, an interfibrillar gel, salts, and water. The epidermis is the topmost layer of skin and where vascularization ends. Due to the lack of vascularization, the transfer of fluids, nutrients, and waste across the epidermis occurs through the epidermal-dermal junction.