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  2. Common Terminology Criteria for Adverse Events - Wikipedia

    en.wikipedia.org/wiki/Common_Terminology...

    The first Iteration was prior to 1998. In 1999, the FDA released version 2.0. CTCAE version 4.0 in 2009 with an update to y version 4.03 in 2010. [2] The current version 5.0 was released on November 27, 2017. Many clinical trials, now extending beyond oncology, encode their observations based on the CTCAE system. It uses a range of grades from ...

  3. Ethinylestradiol - Wikipedia

    en.wikipedia.org/wiki/Ethinylestradiol

    A combination of 20 μg/day EE and 0.25 mg/day levonorgestrel, a progestin with relatively high androgenicity, decreases SHBG levels by 50%; 30 μg/day EE and 0.25 mg/day levonorgestrel has no effect on SHBG levels; 30 μg/day EE and 0.15 mg/day levonorgestrel increases SHBG levels by 30%; and triphasic COCs containing EE and levonorgestrel ...

  4. Pharmacodynamics of estradiol - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of_estradiol

    Estradiol is an estrogen, or an agonist of the nuclear estrogen receptors (ERs), the estrogen receptor alpha (ERα) and the estrogen receptor beta (ERβ). [1] [2] [6] In one study, the EC 50 Tooltip half-maximal effective concentration value of estradiol for the human ERα was 50 pM (0.05 nM) and for the human ERβ was 200 pM (0.2 nM).

  5. Rosa DeLauro - Wikipedia

    en.wikipedia.org/wiki/Rosa_DeLauro

    Rosa Luisa DeLauro [1] [2] (/ d ɪ ˈ l ɔː r oʊ / dih-LOR-oh; born March 2, 1943) is an American politician who is in her 18th term the U.S. representative for Connecticut's 3rd congressional district, having served since 1991.