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Although rosacea was first described by Guy de Chauliac in the 14th century and included Chaucer's The Canterbury Tales, [2] when the National Rosacea Society was founded in 1992 rosacea was still considered a rare disease, and its first approved treatment, topical metronidazole, received orphan drug designation by the U.S. Food and Drug Administration in the belief that fewer than 200,000 ...
Metronidazole has been studied in various immunological disorders, including inflammatory bowel disease, periodontitis, and rosacea. In these conditions, metronidazole has been suspected to have anti-inflammatory and immunomodulatory effects that could be beneficial in the treatment of these conditions. [85]
Rosacea conglobata is a severe rosacea that can mimic acne conglobata, with hemorrhagic nodular abscesses and indurated plaques. [26] Phymatous rosacea is a cutaneous condition characterized by overgrowth of sebaceous glands. [11] Phyma is Greek for swelling, mass, or bulb, and these can occur on the face and ears. [26]: 693
Topical 0.75% and 1% Metronidazole [10] [11] Topical 4% nicotinamide [3] Topical sulfacetamide [11] Tea tree oil [12] Cannabidiol shampoo [24] Frequent washing to avoid the build-up of scale, especially on the scalp, but while avoiding overly drying the skin [12] [11] [20] Avoiding damaging skin with harsh grooming or chemical irritants [20]
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