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2. Direct factor Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

   The monitoring of warfarin and keeping the international normalized ratio (INR) between 2.0 and 3.0, along with avoiding over and under treatment, has driven a search for an alternative. [3] [14] A naturally occurring inhibitor of factor Xa was reported in 1971 by Spellman et al. from the dog hookworm. [15]

3. 15 Most Common Puppy Health Issues and How to Spot Them - AOL

   www.aol.com/15-most-common-puppy-health...

   The treatment is just an antibiotic, and most puppies do fine after medication, but you do need to take your puppy to your local veterinarian so that the stool can be examined under a microscope.

4. Rivaroxaban - Wikipedia

   en.wikipedia.org/wiki/Rivaroxaban

   Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]

5. 7 Alternatives to Chemotherapy for Lymphoma in Dogs - AOL

   www.aol.com/7-alternatives-chemotherapy-lymphoma...

   1. Ketogenic Diet. Cancer cells rely on glucose for energy to grow. The ketogenic diet is a way to provide an alternative energy source to normal cells in the dog's body while starving the cancer ...

6. Benadryl for Dogs? A Vet Explains How Much You Should Give - AOL

   www.aol.com/benadryl-dogs-vet-explains-much...

   It should be 100% diphenhydramine, not Benadryl-D or any other product. Although Benadryl is safe, giving your dog decongestants like pseudoephedrine can cause: Depression. Weakness. Vomiting ...

7. Discovery and development of direct Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.