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[15] [13] [14] Estradiol valerate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [ 5 ] [ 4 ] [ 16 ] It is an estrogen ester and a prodrug of estradiol in the body.
EE is a long-acting estrogen, with a nuclear retention of about 24 hours. [40] Orally, EE is on the order of 100 times as potent by weight as natural estrogens like micronized estradiol and conjugated estrogens, which is largely due to substantially greater resistance to first-pass metabolism.
Estradiol is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the biological target of estrogens like endogenous estradiol. [10] Due to its estrogenic activity, estradiol has antigonadotropic effects and can inhibit fertility and suppress sex hormone production in both women and men.
Gynecomastia in older men is estimated to be present in 24–65 percent of men between the ages of 50 and 80. Estimates on asymptomatic gynecomastia is about up to 70% in men aged 50 to 69 years. [26] [50] The prevalence of gynecomastia in men may have increased in recent years, but the epidemiology of the disorder is not fully understood. [40]
Breast cancer was increased in women treated with estrogen and a progestin, but not with estrogen and progesterone or estrogen alone. Treatment with unopposed estrogen (i.e., an estrogen alone without a progestogen) is contraindicated if the uterus is still present, due to its proliferative effect on the endometrium. The WHI also found a ...
After gaining weight during the Covid-19 pandemic, Harvey Fierstein says that he’s now lost 120 lbs., — all thanks to weight-loss medication. In typically irreverent Fierstein fashion, ...
Estrogen is the predominant sex hormone that slows bone loss (even in men). Both estrogen and testosterone help stimulate bone formation (T, especially at puberty). Testosterone may cause an increase in cortical bone thickness in transgender men (however this does not necessarily translate to a greater mechanical stability).
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