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Intravenous iron therapy has an established role in the treatment of iron deficiency anaemia when oral supplements are ineffective or cannot be used. [12] IV iron infusions can administer the exact dose of iron to normalise levels in the blood. [7] Pre-operative anaemia is associated with high risk of death.
Iron preparation is the formulation for iron supplements indicated in prophylaxis and treatment of iron-deficiency anemia. Examples of iron preparation include ferrous sulfate, ferrous gluconate, and ferrous fumarate. It can be administered orally, and by intravenous injection, or intramuscular injection. [1] Early Iron Supplement for Anemia
Injectable forms include iron dextran and iron sucrose. [13] They work by providing the iron needed for making red blood cells. [14] Iron pills have been used medically since at least 1681, with an easy-to-use formulation being created in 1832 using Chicken Liver extracts and majority from plants. [15]
The 2020 Cochrane Anaesthesia Review Group review of erythropoietin (EPO) plus iron versus control treatment including placebo or iron for preoperative anaemic adults undergoing non‐cardiac surgery [11] demonstrated that patients were much less likely to require red cell transfusion and in those transfused, the volumes were unchanged (mean ...
Iron sucrose has also been shown to significantly lower the risk of gastrointestinal problems when compared to oral iron treatments. It has a much lower rate of serious allergic reactions in comparison to other iron substitution treatments (around 0.002% in iron sucrose in comparison to 0.04-2.3% in other treatments).
Dextran is used to make microcarriers for industrial cell culture; Orally-administered dextran sodium sulphate is used to induce colitis in animal models of inflammatory bowel disease. [12] Dextran is a common model compound to test the potential of drug formulations to facilitate intestinal absorption via the paracellular route. [13]
Dextran 70 is a type of fluid given by injection into a vein to expand blood volume. [1] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available. [2] However, it does not carry oxygen. [2] Common side effects include vomiting, fever, and joint pains. [2]
Evidence suggests that the use of bisphosphonates would be useful in the treatment of complex regional pain syndrome, a neuro-immune problem with high MPQ scores, low treatment efficacy and symptoms which can include regional osteoporosis. In 2009 bisphosphonates were "among the only class of medications that has survived placebo-controlled ...