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pentoxyfylline – xanthine derivative used in as an antiinflammatory drug and in the prevention of endotoxemia; pergolide – dopamine receptor agonist used for the treatment of pituitary pars intermedia dysfunction in horses; phenobarbital – anti-convulsant used for seizures; phenylbutazone – nonsteroidal anti-inflammatory drug (NSAID)
Detomidine is a sedative with analgesic properties. [3] α 2-adrenergic receptor agonists produce dose-dependent sedative and analgesic effects, mediated by activation of α 2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters.
Calciseptine has been shown to specifically inhibit the L-type voltage-gated Ca 2+ channels and was the first natural polypeptide discovered with this property. Specific polypeptide inhibitors of voltage-sensitive channels are important tools in research, and were already known for voltage-sensitive Na + channels, both voltage-sensitive and Ca 2+-activated K + channels, and for N-type Ca 2 ...
Interest in determining which sires of race horses transmit raw speed, and which sires transmit stamina (defined as the ability to successfully compete at longer distances) to their progeny dates back to the early 20th century, when a French researcher, Lt. Col. J. J. Vuillier, published a study on the subject (called Dosage), which was subsequently modified by an Italian breeding expert, Dr ...
It is less effective as a sedative if the horse is already excited. [23] Additionally, acepromazine is used as a vasodilator in the treatment of laminitis, where an oral dose equivalent to "mild sedation" is commonly used, although the dose used is highly dependent on the treating veterinarian. While it is shown to elicit vasodilation in the ...
It never became a registered drug in the United States. The brand was transferred to Desitin GmbH in 1993 and is sold in several European countries, in Israel, Japan, and Australia. Sultiame became established as a second-line drug for treatment of partial epilepsy in the 1960s and 1970s and was often used in combination with the established ...
The cream gene (C Cr) is an incomplete dominant allele with a distinct dosage effect. The DNA sequence responsible for the cream colors is the cream allele, which is at a specific locus on the solute carrier family 45 member 2 gene (previously known as MATP and OCA4, among others). Its general effect is to lighten the coat, skin and eye colors.
Chloral hydrate/magnesium sulfate/pentobarbital sodium, brand name Equithesin, is a combination anesthetic agent used as a general anesthetic in horses. [1] It is administered intravenously to effect. For many years, it was the most commonly used injectable anesthetic in horses.